Статьи с метками bronchial asthma

ROLE OF AUTOIMMUNE DISORDERS IN THE PATHOGENESIS OF CEREBROVASCULAR INSUFFICIENCY IN CHILDREN WITH BRONCHIAL ASTHMA

PUMTS. 2021; 41(1): 37-43. https://doi.org/10.31071/promedosvity2021.01.037 It has been shown that the main spectrum of immunopathological reactions in bronchial asthma in children has a clear antigenic dependence not only on the inflammatory-activated intermediate stroma of the bronchopulmonary system, but also on the effects of autoantibodies on cerebral vessels and cell tissue. insufficiency of this contingent of […]

EXPERIMENTAL REPRODUCTION OF BRONCHIAL ASTHMA ІN LABORATORY ANIMALS AS A MODEL FOR REFINING ETIOPATHOGENESIS AND DRUGS INCLUDED ІN THE TREATMENT PROTOCOL

PUMTS. 2020; 37(1): 51-55. https://doi.org/10.31071/promedosvity2020.01.051 The aim of the work was to conduct experimental reproduction of asthma in laboratory animals, observing the maximum identity of its clinical manifestation and natural death in the absence of treatment. During the study, 30 guinea pigs were immunized by intravenous administration of cytokines produced in the supernatant by sensitized […]

PRINCIPLES OF IMMUNOCORRECTIVE THERAPY IN CHILDREN WITH BRONCHIAL ASTHMA

PUMTS. 2018; 29(2): 23-28 https://doi.org/10.31071/promedosvity2018.02.023 The paper presents data on the use of immunocorrective therapy in children with bronchial asthma with isolated autoantibodies from H1-blockers of histamine of the first generation with taewegil and suprastin, which removes autoimmune reactions in the bronchopulmonary system by inhibiting the action of anti-idiotypic antibodies. The effect of immunocorrective therapy […]

THE EFFECT OF PENTOXIFYLLINE (TRENTAL) ON THE PRODUCTION OF CYTOKINES WITH SENSITIZED T-LYMPHOCYTES IN BRONCHIAL ASTHMA IN CHILDREN

PUMTS. 2018; 28(1): 26-32. https://doi.org/10.31071/promedosvity2018.01.026 At the present stage of the development of the problem in the pathogenesis of bronchial asthma, the proinflammatory cytokines of sensitized T-­lymphocytes TNF-α, IL­-4, IL-­1β are increasing in importance in the blood serum level from light to severe bronchial asthma. The immune system controls the antibodies of these cytokines, the […]

АPPLICATION OF INTERFERON INDUCERS (CYCLOFERON) IN THE THERAPY PROTOCOLS FOR CHILDREN WITH BRONCHIAL ASTHMA

PUMTS. 2017; 25(2): 39-48. https://doi.org/10.31071/promedosvity2017.02.039 A promising direction in improving the methods of treatment of asthma in children is to include in the protocol the basic treatment of immunomo- dulatory drugs. Purpose — to estimate immunomo- dulatory properties of interferon inducer (cyclofe- ron) in the protocol treatment of asthma in children. The results of research […]

IMMUNOLOGICAL CONTROL OF INFLAMMATORY CYTOKINES IN CHILDREN WITH ASTHMA

In immunogenesis asthma in children are increa­ singly paying attention to the researchers cytokines sensitized T lymphocyte — tumor necrosis factor — a (TNF-α), interleukin 4 (IL-4) and interleukin 1b (IL-1b). Hyperproduction these cytokines in the body of children with asthma, according to the physiological mechanisms should be regulated by the immune system itself, its […]

Experimental and clinical substantiation bronchoconstrictor properties of inflammatory cytokines in children with asthma

In the pathogenesis of asthma in children, regardless of the etiology of the case features of an autoimmune component triggering the production sensitized T-lymphocytes inflammatory cytokines cause the development of chronic allergic inflammation in the broncho-pulmonary system. Purpose — to study experimentally proinflammatory cytokines sensitized T-lymphocytes that have bronchoconstrictor properties. Results Stu­dies — on the […]