ИНСОМНИЯ И ГАСТРОЭЗОФАГЕАЛЬНАЯ РЕФЛЮКСНАЯ БОЛЕЗНЬ: ОСОБЕННОСТИ ТЕЧЕНИЯ, МЕХАНИЗМЫ ВОЗНИКНОВЕНИЯ И ПУТИ КОРРЕКЦИИ

Probl bezperervnoï med osv nauki. 2019; 35(3): 62-67.
https://doi.org/10.31071/promedosvity2019.03.062

Полный текст (PDF)

В работе показано, что инсомния является одной из актуальных коморбидных патологий при гастроэзофагеальной рефлюксной болезни (ГЭРБ). При ГЭРБ отмечаются основные особенности инсомнии: нарушение сна увеличивается с возрастом и поражает чаще женщин, пациенты имеют легкую и умеренную инсомнию, по опроснику PSQI достоверные различия обнаружены в выраженной дневной сонливости, существенно снижен физический компонент качества жизни, симптоматика ГЭРБ, включая инсомнию, более выражена у пациентов с неэрозивной рефлюксной болезнью. Основные причины нарушения сна при ГЭРБ: рефлюкс, ночная изжога, тревога и депрессия. Среди этих факторов одно из ведущих мест принадлежит психосоматическим нарушениям. Среди направлений коррекции инсомнии при ГЭРБ выделяют: дополнительный прием ингибиторов протонной помпы в вечернее время, прием рамелтеона и препаратов мелатонина. Связь между нарушением сна и симптоматикой ГЭРБ является двунаправленной, как и между депрессией и бессонницей.

СПИСОК ИСПОЛЬЗОВАННЫХ ИСТОЧНИКОВ

1. Гастроезофагеальна рефлюксна хвороба та її рефрактерна форма: сучасні уявлення про діагностику і лікування : навч. посіб. / Т. Д. Звягінцева та ін. Харків : Друкарня Мадрид, 2017. 110 с.
2. Трофимов В., Безруков Ю. Психосоматические аспекты лечения ГЭРБ // Архивъ внутренней медицины. 2015. № 5 (25). С. 55–61.
3. Щербиніна М. Гастроезофагеальна рефлюксна хвороба. Київ : Медкнига, 2013. 106 с.
4. Association of sleep dysfunction and emotional status with gastroesophageal reflux disease in Korea / J. Y. Kim, N. Kim, P. J. Seo et al. // Journal of Neurogastroenterology and Motility. 2013. Vol. 19 (3). P. 344–354. URL: https://doi.org/10.5056/jnm.2013.19.3.344.
5. Böhmer A. C., Schumacher J. Insights into the genetics of gastroesophageal reflux disease (GERD) and GERD-related disorders // Neurogastroenterology and Motility. 2017. Vol. 29, Iss. 2. P. 1–5. URL: https://doi.org/10.1111/nmo.13017.
6. Characteristics of Sleep Disturbances in Patients with Gastroesophageal Reflux Disease / N. Iwakura, Y. Fujiwara, M. Shiba et al. // Internal Medicine. 2016. Vol. 55 (12). P. 1511–1517. URL: https://doi.org/10.2169/internalmedicine.55.5454.
7. Clinical characteristics and psychosocial impact of different reflux time in gastroesophageal reflux disease patients / J. H. Chen, S. H. Wen, C. S. Hsu et al. // Journal of the Formosan Medical Association. 2017. Vol. 116, Iss. 2. P. 123–128. URL: https://doi.org/10.1016/j.jfma.2016.01.016.
8. Effect of Esomeprazole on Nighttime Heartburn and Sleep Quality in Patients with GERD: A Randomized, Placebo-Controlled Trial / D. A. Johnson, W. C. Orr, J. A. Crawley et al. // The American Journal of Gastroenterology. 2005. Vol. 100(9). P. 1914–1922. URL: https://doi.org/10.1111/j.1572-0241.2005.00285.x.
9. Expert consensus document: Advances in the physiological assessment and diagnosis of GERD / E. Savarino, A. J. Bredenoord, М. Fox et al. // Nature Reviews Gastroenterology & Hepatology. 2017. Vol. 14 (11). P. 665–676. URL: https://doi.org/10.1038/nrgastro.2017.130.
10. Gastroesophageal Reflux and Sleep Disturbances: A Bidirectional Association in a Population-Based Cohort Study, The HUNT Study / A. Lindam, Ness-E. Jensen, C. Jansson et al. // Sleep. 2016. Vol. 39 (7). P. 1421–1427. URL:https://doi.org/10.5665/sleep.5976.
11. Gastroesophageal reflux disease symptoms and dietary behaviors are significant correlates of short sleep duration in the general population: the Nagahama Study / K. Murase, Y. Tabara, Y. Takahashi et al. // Sleep. 2014. Vol. 37, Iss. 11. P. 1809–1815. URL: https://doi.org/10.5665/sleep.4176.
12. Global prevalence of, and risk factors for, gastro-oesophageal reflux symptoms: A meta-analysis / L. H. Eusebi, R. Ratnakumaran, Y. Yuan et al. // Gut. 2018. Vol. 67 (3). P. 430–440. URL:https://doi.org/10.1136/gutjnl-2016-313589.
13. Guan X. L., Wang H. Quality of life scales for patients with gastroesophageal reflux disease: A literature review // International Journal of Nursing Sciences. 2015. Vol. 2, Iss. 1. P. 110–114. URL: https://doi.org/10.1016/j.ijnss.2015.02.003.
14. Gyawali C. P., Fass R. Management of Gastroesophageal Reflux Disease // Gastroenterology. 2018. Vol. 154(2). P. 302–318. URL: https://doi.org/10.1053/j.gastro.2017.07.049.
15. Johnson D. A. Gastroesophageal reflux disease and sleep disorders: A wake-up call for physicians and their patients // Reviews in Gastroenterological Disorders. 2005. Vol. 5 (SUPPL. 2). S3–S11. URL: http://www.embase.com/search/results?subaction=viewrecord&from=export&id=L43009608.
16. Kim G. H. It Is Time to Meet the Challenges of the Changing Epidemiology of Gastroesophageal Reflux Disease // Journal of Neurogastroenterology and Motility. 2018. Vol. 24(4). P. 507–509. URL: https://doi.org/10.5056/jnm18152.
17. Korniienko D., Oparin A. The use of ultrasound methods for the diagnosis of motor and evacuation disorders in gastroesophageal reflux disease with concomitant obesity // Oxford Review of Education and Science. 2016. Vol. 1(11). Р. 414–419.
18. Lim K. G., Morgenthaler T. I., Katzka D. A. Sleep and Nocturnal Gastroesophageal Reflux: An Update // Chest. 2018. Vol. 154 (4). P. 963–971. URL: https://doi.org/10.1016/j.chest.2018.05.030.
19. Oh J. H. Gastroesophageal reflux disease: recent advances and its association with sleep // Annals of the New York Academy of Sciences. 2016. Vol. 1380 (1). P. 195–203. URL: https://doi.org/10.1111/nyas.13143.
20. Okuyama M., Takaishi O., Nakahara K. Associations among gastroesophageal reflux disease, psychological stress, and sleep disturbances in Japanese adults // Scandinavian Journal of Gastroenterology. 2017. Vol. 52(1). P. 44–49. URL: https://doi.org/10.1080/00365521.2016.1224383.
21. Oparin A., Kornienko D. Formation process of motor-evacuatory disorders in patients with gastroesophageal reflux disease and concomitant obesity // Gastroenterologie a Hepatologie. 2017. Vol. 71 (2). P. 145–149. URL: https://doi.org/10.14735/amgh2017csgh.info01.
22. Oparin A., Vnukova A. The role of the endothelial dysfunction in the mechanism of formation of gastroesophageal reflux disease in patients with ischemic heart disease // Acta Clinica Croatica. 2017. Vol. 56. P. 635–639. URL: https://doi.org/10.20471/acc.2017.56.04.08.
23. Oparin A. A., Oparin A. G., Kudriavtsev A. A. Role of oxidative stress in formation mechanisms of gastroesophageal reflux disease in patients with diabetes mellitus type II and its correction // The New Armenian Medical Journal. 2018. Vol. 12, Nо 3. P. 67–72.
24. Oparin А., Bezjazichnaya N. Implementation mechanisms of psychosomatic disorders in gastroesophageal reflux disease with concomitant chronic obstructive pulmonary disease // Medica Jadertina. 2016. Vol. 46, No. 1–2. P. 125–132.
25. Prevalence of and impact of pantoprazole on nocturnal heartburn and associated sleep complaints in patients with erosive esophagitis / S. Kindt, J. Imschoot & J. Tack et al. // Diseases of the Esophagus. 2010. Vol. 24 (8). P. 531–537. URL: https://doi.org/10.1111/j.1442-2050.2011.01189.x.
26. Prevalence of Gastroesophageal Reflux Disease in Major Depressive Disorder: A Population-Based Study / P.-H. Chou, C.-C. Lin, C.-H. Lin et al. // Psychosomatics. 2014. Vol. 55 (2). P. 155–162. URL: https://doi.org/10.1016/j.psym.2013.06.003.
27. Rapid resolution of sleep disturbances related to frequent reflux: effect of esomeprazole 20 mg in two randomized, double-blind, controlled trials / D. A. Johnson, A. Le Moigne, V. Hugo et al. // Current Medical Research and Opinion. 2015. Vol. 31 (2). P. 243–250. URL: https://doi.org/10.1185/03007995.2014.991818.
28. Relationships between sleep disturbances and gastroesophageal reflux disease in Asian sleep clinic referrals / G. Ju, I. Y. Yoon, S. D. Lee et al. // Journal of Psychosomatic Research. 2013. Vol. 75 (6). P. 551–555. URL: https://doi.org/10.1016/j.jpsychores.2013.10.004.
29. Risk of psychiatric disorders following gastroesophageal reflux disease: A nationwide population-based cohort study / Z. H. You, C. L.Perng, L. Y. Hu et al. // European Journal of Internal Medicine. 2015. Vol. 26 (7). P. 534–539. URL: https://doi.org/10.1016/j.ejim.2015.05.005.
30. Sleep Dysfunction in Japanese Patients with Gastroesophageal Reflux Disease: Prevalence, Risk Factors, and Efficacy of Rabeprazole / Y. Fujiwara, Y. Kohata, M. Kaji et al. // Digestion. 2010. Vol. 81(3). P. 135–141. URL: https://doi.org/10.1159/000253849.
31. The association between gastroesophageal reflux disease with sleep quality, depression, and anxiety in a cohort study of Australian men / Z. X. On, J. Grant, Z. Shi et al. // Journal of Gastroenterology and Hepatology.2017. Vol. 32 (6). P. 1170–1177. URL: https://doi.org/10.1111/jgh.13650.
32. The effect of ramelteon on heartburn symptoms of patients with gastroesophageal reflux disease and chronic insomnia a pilot study / L. K. Jha, R. Fass, R. Gadam et al. // Journal of Clinical Gastroenterology. 2016. Vol. 50 (2). P. 19–24. URL: https://doi.org/10.1097/MCG.0000000000000322.

REFERENCES

1. Zviahintseva, T. D., Serhiienko, O. I., Chernobai, A. I., Sharhorod, I. I., & Hridnieva, S. V. (2017). Hastroezofahealna refliuksna khvoroba ta yii refrakterna forma: suchasni uiavlennia pro diahnostyku I likuvannia [Gastroesophageal reflux disease and its refractory form: modern imagination on diagnostics and treatment]. Kharkiv: Drukarnia Madryd, 110.
2. Trophimov, V., Bezrukov, Yu. (2015). Psyschosomatic aspects of GERD treatment. Internal Medicine Archive, 5 (25), 55-61.
3. Shcherbynina, M. (2013). Hastroezofahealna refliuksna khvoroba [Gastroesophageal reflux disease]. Kyiv: Medknyha, 106.
4. Kim, J. Y., Kim, N., Seo, P. J., Lee, J. W., Kim, M. S., Kim, S. E., … Jung, H. C. (2013). Association of sleep dysfunction and emotional status with gastroesophageal reflux disease in Korea. Journal of Neurogastroenterology and Motility, Vol. 19(3), 344-354. https://doi.org/10.5056/jnm.2013.19.3.344
5. Böhmer, A. C., & Schumacher, J. (2017). Insights into the genetics of gastroesophageal reflux disease (GERD) and GERD-related disorders. Neurogastroenterology and Motility, 29, 2. 1-5. https://doi.org/10.1111/nmo.13017
6. Iwakura, N., Fujiwara, Y., Shiba, M., Ochi, M., Fukuda, T., Tanigawa, T., & Arakawa, T. (2016). Characteristics of Sleep Disturbances in Patients with Gastroesophageal Reflux Disease. Internal Medicine, 55(12), 1511-1517. https://doi.org/10.2169/internalmedicine.55.5454
7. Chen, J. H., Wen, S. H., Hsu, C. S., Yi, C. H., Liu, T. T., Chen, C. L., & Wang, C. C. (2017). Clinical characteristics and psychosocial impact of different reflux time in gastroesophageal reflux disease patients. Journal of the Formosan Medical Association, 116, 2, 123-128. https://doi.org/10.1016/j.jfma.2016.01.016
8. Johnson, D. A., Orr, W. C., Crawley, J. A., Traxler, B., McCullough, J., Brown, K. A., & Roth, T. (2005). Effect of Esomeprazole on Nighttime Heartburn and Sleep Quality in Patients with GERD: A Randomized, Placebo- Controlled Trial. The American Journal of Gastroenterology, 100 (9), 1914-1922. https://doi.org/10.1111/j.1572-0241.2005.00285.x
9. Savarino, E., Bredenoord, A. J., Fox, M., Pandolfino, J. E., Roman, S., & Gyawali, C. P. (2017). Expert consensus document: Advances in the physiological assessment and diagnosis of GERD Nature. Reviews Gastroenterology & Hepatology, 14 (11), 665-676. https://doi.org/10.1038/nrgastro.2017.130
10. Lindam, A., Ness-Jensen, E., Jansson, C., Nordenstedt, H., Åkerstedt, T., Hveem, K. & Lagergren, J. (2016). Gastroesophageal Reflux and Sleep Disturbances: A Bidirectional Association in a Population-Based Cohort Study, The HUNT Study. Sleep, 39 (7), 1421-1427. https://doi.org/10.5665/sleep.5976
11. Murase, K., Tabara, Y., Takahashi, Y., Muro, S., Yamada, R., Setoh, K., … Matsuda, F. (2014). Gastroesophageal reflux disease symptoms and dietary behaviors are significant correlates of short sleep duration in the general population: the Nagahama Study. Sleep, 37, 11, 1809-1815. https://doi.org/10.5665/sleep.4176
12. Eusebi, L. H., Ratnakumaran, R., Yuan, Y., Solaymani-Dodaran, M., Bazzoli, F., & Ford, A. C. (2018). Global prevalence of, and risk factors for, gastro-oesophageal reflux symptoms: A meta-analysis. Gut, 67 (3), 430-440. https://doi.org/10.1136/gutjnl-2016-313589
13. Guan, X. L., & Wang, H. (2015). Quality of life scales for patients with gastroesophageal reflux disease: A literature review International. Journal of Nursing Sciences, 2, 1, 110-114. https://doi.org/10.1016/j.ijnss.2015.02.003
14. Gyawali, C. P., & Fass, R. (2018). Management of Gastroesophageal Reflux Disease. Gastroenterology, 154 (2), 302-318. https://doi.org/10.1053/j.gastro.2017.07.049
15. Johnson, D. A. (2005). Gastroesophageal reflux disease and sleep disorders: A wake-up call for physicians and their patients. Reviews in Gastroenterological Disorders, 5(2), S3-S11.
16. Kim, G. H. (2018). It Is Time to Meet the Challenges of the Changing Epidemiology of Gastroesophageal Reflux Disease. Journal of Neurogastroenterology and Motility, 24 (4), 507-509. https://doi.org/10.5056/jnm18152
17. Korniienko, D., & Oparin, A. (2016). The use of ultrasound methods for the diagnosis of motor and evacuation disorders in gastroesophageal reflux disease with concomitant obesity. Oxford Review of Education and Science, 1 (11), 414-419.
18. Lim, K. G., Morgenthaler, T. I., & Katzka, D. A. (2018). Sleep and Nocturnal Gastroesophageal Reflux: An Update. Chest, 154 (4), 963-971. https://doi.org/10.1016/j.chest.2018.05.030
19. Oh, J. H. (2016). Gastroesophageal reflux disease: recent advances and its association with sleep. Annals of the New York Academy of Sciences, 1380 (1), 195-203. https://doi.org/10.1111/nyas.13143
20. Okuyama, M., Takaishi, O., Nakahara, K., Iwakura, N., Hasegawa, T., Oyama, & M., Fujiwara, Y. ( 2017). Associations among gastroesophageal reflux disease, psychological stress, and sleep disturbances in Japanese adults Scandinavian. Journal of Gastroenterology, 52 (1), 44-49. https://doi.org/10.1080/00365521.2016.1224383
21. Oparin, A., & Kornienko, D. (2017). Formation process of motor-evacuatory disorders in patients with gastroesophageal reflux disease and concomitant obesity. Gastroenterologie a Hepatologie, 71 (2), 145-149. https://doi.org/10.14735/amgh2017csgh.info01
22. Oparin, A., & Vnukova, A. (2017). The role of the endothelial dysfunction in the mechanism of formation of gastroesophageal reflux disease in patients with ischemic heart disease. Acta Clinica Croatica, 56, 635-639. https://doi.org/10.20471/acc.2017.56.04.08
23. Oparin, A. A., Oparin, A. G., & Kudriavtsev, A. A. (2018). Role of oxidative stress in formation mechanisms of gastroesophageal reflux disease in patients with diabetes mellitus type II and its correction. The New Armenian Medical Journal, 12, 3, 67-72.
24. Oparin, А., & Bezjazichnaya, N. (2016). Implementation mechanisms of psychosomatic disorders in gastroesophageal reflux disease with concomitant chronic obstructive pulmonary disease. Medica Jadertina, 46, 1-2, 125-132.
25. Kindt, S., Imschoot, J., & Tack, J. (2010). Prevalence of and impact of pantoprazole on nocturnal heartburn and associated sleep complaints in patients with erosive esophagitis. Diseases of the Esophagus, 24 (8), 531-537. https://doi.org/10.1111/j.1442-2050.2011.01189.x
26. Chou, P.-H., Lin, C.-C., Lin, C.-H., Tsai, C.-J., Cheng, C., Chuo, Y.-P., … Lan, T.-H. (2014). Prevalence of Gastroesophageal Reflux Disease in Major Depressive Disorder: A Population-Based Study. Psychosomatics, 55 (2), 155-162. https://doi.org/10.1016/j.psym.2013.06.003
27. Johnson, D. A., Le Moigne, A., Hugo, V., & Nagy, P. (2015). Rapid resolution of sleep disturbances related to frequent reflux: effect of esomeprazole 20 mg in two randomized, double-blind, controlled trials. Current Medical Research and Opinion, 31(2), 243-250. https://doi.org/10.1185/03007995.2014.991818
28. Ju, G., Yoon, I.-Y., Lee, S. D., & Kim, N. (2013). Relationships between sleep disturbances and gastroesophageal reflux disease in Asian sleep clinic referrals. Journal of Psychosomatic Research, 75 (6), 551-555. https://doi.org/10.1016/j.jpsychores.2013.10.004
29. You, Z. H., Perng, C. L., Hu, L. Y., Lu, T., Chen, P. M., Yang, A. C., Chen, H. J. (2015). Risk of psychiatric disorders following gastroesophageal reflux disease: A nationwide population-based cohort study. European Journal of Internal Medicine, 26 (7), 534-539. https://doi.org/10.1016/j.ejim.2015.05.005
30. Fujiwara, Y., Kohata, Y., Kaji, M., Nebiki, H., Yamasaki, T., Sasaki, E., … Arakawa, T. (2010). Sleep Dysfunction in Japanese Patients with Gastroesophageal Reflux Disease: Prevalence, Risk Factors, and Efficacy of Rabeprazole. Digestion, 81 (3), 135-141. https://doi.org/10.1159/000253849
31. On, Z. X., Grant, J., Shi, Z., Taylor, A. W., Wittert, G. A., Tully, P. J., & Martin, S. (2017). The association between gastroesophageal reflux disease with sleep quality, depression, and anxiety in a cohort study of Australian men. Journal of Gastroenterology and Hepatology, 32 (6), 1170-1177. https://doi.org/10.1111/jgh.13650
32. Jha, L. K., Fass, R., Gadam, R., Maradey-Romero, C., Nasrollah, L., Hershcovici, T., … Dickman, R. (2016). The effect of ramelteon on heartburn symptoms of patients with gastroesophageal reflux disease and chronic insomnia a pilot study. Journal of Clinical Gastroenterology, 50 (2), 19-24. https://doi.org/10.1097/MCG.0000000000000322

Ключевые слова: гастроэзофагеальная рефлюксная болезнь, ингибиторы протон- ной помпы, инсомния, мелатонин, рамелтеон