THE EFFECT OF PENTOXIFYLLINE (TRENTAL) ON THE PRODUCTION OF CYTOKINES WITH SENSITIZED T-LYMPHOCYTES IN BRONCHIAL ASTHMA IN CHILDREN

PUMTS. 2018; 28(1): 26-32.
https://doi.org/10.31071/promedosvity2018.01.026

At the present stage of the development of the problem in the pathogenesis of bronchial asthma, the proinflammatory cytokines of sensitized T-­lymphocytes TNF-α, IL­-4, IL-­1β are increasing in importance in the blood serum level from light to severe bronchial asthma. The immune system controls the antibodies of these cytokines, the reliability of which is determined by the moderate and severe course of the disease. It was shown that pentoxifylline in vitro inhibits the production of proinflammatory cytokines of sensitized T-­lymphocytes in nutrient medium 199, cultured with lipopolysaccharide antigens of bronchi and lung tissue. Studies are promising and of great practical importance to approaches to the treatment of this pathology.

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