АPPLICATION OF INTERFERON INDUCERS (CYCLOFERON) IN THE THERAPY PROTOCOLS FOR CHILDREN WITH BRONCHIAL ASTHMA

A promising direction in improving the methods of treatment of asthma in children is to include in the protocol the basic treatment of immunomo- dulatory drugs. Purpose to estimate immunomo- dulatory properties of interferon inducer (cyclofe- ron) in the protocol treatment of asthma in children. The results of research the use of interferon indu cer cycloferon combined with basic therapy drugs leads to an immunomodulating effect on phago cytes: the restoration of the synthesis of IFN-α, IFN-γ; by humoral immunity: increase in IgA and the trend towards normalization of markers of CD3+, CD4+ , CD8with a light and a trend toward normalization with moderate and severe disease. The inhibitory effect on the apoptosis process, as it marks the early stages — sFASL (CD178) Caspase-1, and late stages CD95 and Annexin V protein, allowing the development of longterm clinical remission in this group of children.

 

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